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The Holiday Inn Express along Corridor G in South Charleston has been evacuated after carbon monoxide was detected inside the building.
Kanawha County 911 Dispatchers tell WSAZ.com a man was found dead in the hotel and three others taken to the hospital.
One man was seriously injured. The other two victims were taken to the hospital as a precaution.
A South Charleston Firefighter tells WSAZ.com the two men were found on the 5th floor of the hotel.
Firefighters say there were extremely high levels of carbon monoxide found on several floors of the hotel.
About 10 to 15 people were inside the hotel at the time of the evacuation.
Firefighters say the room where the two men were staying did not have a carbon monoxide detector. According to the Assistant Fire Chief, hotels are not required by law to have carbon monoxide detectors, only smoke detectors.